OGSIVEO can help put progressing Desmoid Tumors in their place
Help treat your desmoid tumor with the first and only FDA-approved treatment that can help get progressing desmoid tumors under control for adults who require a medicine by mouth or injection (systemic therapy).1
Learn More About OGSIVEO
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Individual results may vary.

OGSIVEO is the #1 prescribed systemic therapy for adults with desmoid tumors.2 Learn More About OGSIVEO

Guideline Recommendation

The NCCN* Guidelines for Patients® recommend nirogacestat (OGSIVEO) as a treatment option for desmoid tumors that are growing and/or causing symptoms.3

*The National Comprehensive Cancer Network® (NCCN®) is a not-for-profit alliance of leading cancer centers devoted to patient care, research, and education.

OGSIVEO Trial

OGSIVEO was studied in a broad range of patients with desmoid tumors in the largest completed clinical trial of its kind.1,4

  • The trial compared OGSIVEO to placebo (a pill with no active medicine) in 142 adults. 70 people received OGSIVEO, and 72 people received placebo.

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    What is Ogsiveo?
    Important Safety Information

    What is OGSIVEO?  

    OGSIVEO is a prescription medication used to treat adults with progressing desmoid tumors who require a medicine by mouth or injection (systemic therapy). It is not known if OGSIVEO is safe and effective in children.

    Important Safety Information  

    Before taking OGSIVEO tell your healthcare provider about all of your medical conditions, including if you:

    • Have liver problems.
    • Are pregnant or plan to become pregnant. OGSIVEO can harm your unborn baby. Tell your healthcare provider if you become pregnant or think you may be pregnant during treatment.
    • Females who are able to become pregnant:
      • Your healthcare provider will give you a pregnancy test before you start treatment with OGSIVEO.
      • You should use effective birth control during treatment and for 1 week after the last dose. Talk to your healthcare provider about methods that may be right for you.
      • Stop taking OGSIVEO and tell your healthcare provider right away if you become pregnant.
    • Males with female partners who are able to become pregnant should use effective birth control during treatment with OGSIVEO and for 1 week after the last dose.
    • Are breastfeeding or plan to breastfeed. It is not known if OGSIVEO passes into your breast milk. Do not breastfeed during treatment with OGSIVEO and for 1 week after the last dose.

    Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

    You should avoid taking proton pump inhibitors (PPIs) and H2 blockers during treatment with OGSIVEO. Ask your healthcare provider if you are not sure if you take one of these medicines. 

    How should I take OGSIVEO? 

    • Take OGSIVEO exactly as your healthcare provider tells you to take it.
    • Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment with OGSIVEO if you develop side effects.
    • Take OGSIVEO 2 times a day with or without food.
    • Swallow OGSIVEO tablets whole. Do not break, crush, or chew.
    • If you take an antacid medicine, take OGSIVEO 2 hours before or 2 hours after the antacid.
    • If you vomit after taking a dose or miss a dose of OGSIVEO, take your next dose at your regular time. Do not take 2 doses of OGSIVEO to make up the dose.

    What should I avoid while taking OGSIVEO? 

    Avoid eating or drinking grapefruit products, Seville oranges, and starfruit during treatment with OGSIVEO.  

    What are the possible side effects of OGSIVEO? 

    OGSIVEO can cause serious side effects, including:

    • Diarrhea. Diarrhea is common with OGSIVEO and may sometimes be severe. Your healthcare provider may tell you to drink more fluids or to take antidiarrheal medicines. Tell your healthcare provider right away if you have diarrhea that lasts longer than a few days and does not get better after taking antidiarrheal medicines.
    • Ovarian problems. Females who are able to become pregnant may have ovarian problems and changes in their menstrual cycle during treatment. OGSIVEO may affect fertility which may affect your ability to have a child. Tell your healthcare provider if you have any changes in your menstrual cycle or hot flashes, night sweats, or vaginal dryness during treatment.
    • Liver problems. OGSIVEO can increase liver enzymes. Your healthcare provider will do blood tests to check your liver function before you start and during treatment with OGSIVEO.
    • New non-melanoma skin cancers. Your healthcare provider will do skin exams before and during treatment with OGSIVEO if you are at risk for skin cancer. Tell your healthcare provider if you have any new or changing skin lesions.
    • Electrolyte (salt) problems. Your healthcare provider will do blood tests to check your phosphate and potassium levels during treatment and may give you medicines to treat low phosphate or low potassium if needed. Tell your healthcare provider if you develop any muscle pain or weakness.

    Tell your healthcare provider right away if you have any side effect that bothers you or that does not go away. Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment with OGSIVEO.  

    The most common side effects of OGSIVEO are: 

    • rash 
    • nausea 
    • tiredness 
    • mouth sores 
    • headache 
    • stomach (abdominal) pain 
    • cough 
    • hair loss 
    • upper respiratory infection 
    • shortness of breath 

    OGSIVEO can affect fertility in females and males, which may affect your ability to have a child. Talk to your healthcare provider if this is a concern for you.
    These are not all of the possible side effects of OGSIVEO. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

    Please see full Prescribing Information and Patient Information for OGSIVEO.

    What is OGSIVEO?  

    OGSIVEO is a prescription medication used to treat adults with progressing desmoid tumors who require a medicine by mouth or injection (systemic therapy). It is not known if OGSIVEO is safe and effective in children.

    Please see full Prescribing Information and Patient Information for OGSIVEO.

    References
    1. OGSIVEO. Prescribing Information. SpringWorks Therapeutics, Inc.
    2. Data on file. SpringWorks Therapeutics, Inc. February 2025.
    3. Referenced with permission from the NCCN Guidelines for Patients® for Soft Tissue Sarcoma, 2025. © National Comprehensive Cancer Network, Inc. 2025. All rights reserved. Accessed August 7, 2025. To view the most recent and complete version of the NCCN Guidelines for Patients, go online to NCCN.org/patientguidelines. NCCN makes no warranties of any kind whatsoever regarding their content, use, or application, and disclaims any responsibility for their application or use in any way.
    4. Gounder M, Ratan R, Alcindor T, et al. Nirogacestat, a gamma-secretase inhibitor for desmoid tumors. N Engl J Med. 2023;388(10):898-912.