About OGSIVEO

OGSIVEO can help put progressing desmoid tumors in their place.1

What is OGSIVEO?

OGSIVEO is the #1 prescribed systemic therapy for adults with desmoid tumors.2

Help treat your desmoid tumor with the first and only FDA-approved treatment that can help get progressing desmoid tumors under control for adults who require a medicine by mouth or injection (systemic therapy). It is not known if OGSIVEO is safe and effective in children.1

Actor portrayal. Individual results may vary.

Guideline Recommendation

The NCCN* Guidelines for Patients® recommend nirogacestat (OGSIVEO) as a treatment option for desmoid tumors that are growing and/or causing symptoms.3

The National Comprehensive Cancer Network® (NCCN®) is a not-for-profit alliance of leading cancer centers devoted to patient care, research, and education.

OGSIVEO was studied in the largest completed clinical trial of an FDA-approved treatment for adult patients with desmoid tumors.1,4

The trial compared OGSIVEO to placebo (a pill with no active medicine) in 142 adults. 70 people received OGSIVEO, and 72 people received placebo.

Graphic showing the 142 adults randomly assigned to take OGSIVEO® (nirogacestat) or a placebo in the clinical trial for desmoid tumors.

OGSIVEO is shown to be effective and safe—with impactful clinical trial results1,†

OGSIVEO lowered the chance of tumor progression or death

OGSIVEO shrank tumors for some people and, in certain cases, tumors disappeared

Patients reported reduced pain with OGSIVEO

In the study, progression could mean one of two things: 1) The tumor was growing bigger by 20% or more, or 2) The person felt new or worsening symptoms that caused them to stop treatment and leave the study, and start a different type of treatment for the desmoid tumor(s).1,4

Learn more about OGSIVEO

Download a patient brochure for information on OGSIVEO including its possible benefits and side effects.

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OGSIVEO provided effective desmoid tumor control

In the clinical trial, OGSIVEO reduced the chance of a participant’s disease getting worse during the study by 71% compared with a placebo.

This is known as progression-free survival.1,4

OGSIVEO also helped shrink desmoid tumors or caused them to completely disappear in some people1

Percentage of people whose tumors responded—as confirmed by MRI or CT scans

  • When a tumor shrinks by 30% or more, this is known as an objective response.1,4
Graphic stating tumor response with OGSIVEO® (nirogacestat) and placebo.
Graphic stating tumor response with OGSIVEO® (nirogacestat) and placebo.

In patients who responded to OGSIVEO, tumors began to shrink between 2.6 and 19.4 months after starting therapy. The median (middle) amount of time it took for tumors to begin shrinking was 5.6 months, compared to 11.1 months (2.8 to 16.4 months) for patients taking placebo.4

Limitations: This was an exploratory analysis, meaning it was not specifically designed to find differences between OGSIVEO and placebo. Therefore, these results may be due to chance and should be interpreted carefully. Individual results may vary from the clinical trial experience.

Patients reported reduced pain—one of the most common symptoms of desmoid tumors—with OGSIVEO1,4

Person in pain icon

People filled out questionnaires at different points during the trial

  • More than 50% of patients entering the clinical trial had pain. Over the course of the trial, people continued to report their pain
  • People taking OGSIVEO reported reductions in worst pain compared with those taking placebo

Limitations: Meaningful changes in pain levels were difficult to estimate in the clinical trial because not all patients completed the pain questionnaires at each timepoint, and because the number of patients completing questionnaires differed between OGSIVEO and placebo treatment groups. Definitive conclusions cannot be made about the impact of OGSIVEO on pain.

After four years, my oncologist recommended OGSIVEO. After six months, the scans showed that OGSIVEO had helped get my desmoid tumor size under control.
I’ve noticed improvements in pain since I started my treatment. 
I do have prescription pain medication for occasional flare-ups, but thankfully it’s needed much less often.
Christina, Patient Taking OGSIVEO
Watch Christina’s full story and hear other patient voices.
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Individual results may vary.

Doctor Discussion Guide PDF

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The safety of OGSIVEO was evaluated in the clinical trial1

OGSIVEO can cause serious side effects, including:1

  • Diarrhea
  • Ovarian problems
  • Liver problems
  • New non-melanoma skin cancers
  • Electrolyte (salt) problems

OGSIVEO can affect fertility in females and males, which may affect your ability to have a child.


Talk to your healthcare provider if this is a concern for you.1

These are not all of the possible side effects of OGSIVEO. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.1

of side effects in the clinical trial:4

  • were mild or moderate in intensity
  • occurred within 1 month of starting treatment with OGSIVEO

If you think you may be experiencing any side effects, call your healthcare provider. Your healthcare provider may recommend medications or other approaches to help you manage side effects. Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment with OGSIVEO.

Learn more about possible side effects and what you may expect from OGSIVEO.

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OGSIVEO is a systemic therapy

Systemic therapies work throughout the entire body1,5—unlike surgery which is a local therapy, meaning it is typically focused on a single place in the body.6

OGSIVEO is not a chemotherapy. It is thought to work by interfering with gamma secretase—a protein that helps some type of cells grow, including desmoid tumor cells. OGSIVEO may keep desmoid tumor cells from growing.2,7 The precise mechanism of how OGSIVEO works is not known.

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  • OGSIVEO® (nirogacestat) Doctor Discussion Guide PDF OGSIVEO® (nirogacestat) Doctor Discussion Guide PDF

    Create a Customized Doctor Discussion Guide

    Create and use this guide to help you have a productive conversation with your care team.

    Here are some tips that may also help you prepare:

    • Write down your personal experience
    • Be specific about your symptoms
    • Bring these items to your appointment:
      • This guide, either printed or digital form
      • A notepad to take notes
      • A list of all of the medications you are currently taking, including vitamins and supplements

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  • Question 1: Are you taking OGSIVEO?
  • Question 2: Are your symptoms changing, or do you have new symptoms? It may be helpful to keep track of any changes in your symptoms. Tracking symptoms may help your care team determine if they need to make any changes to your care plan.
    Check all symptoms that apply

    This is not a comprehensive list. You can write down any additional symptoms in the notes section of your guide.

    Please indicate level of pain:

    When talking to your doctor, consider describing your pain using specific terms like dull, sharp, throbbing, burning, or aching. It may also be helpful to share the frequency of your pain (eg, constant, intermittent).

    OGSIVEO may not help to treat all or any of these desmoid tumor symptoms.

    Next Step
  • Question 3: What questions do you have about OGSIVEO?
    Check all that apply
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Frequently asked questions about OGSIVEO

What is OGSIVEO?

OGSIVEO is a prescription medication used to treat adults with progressing desmoid tumors who require a medicine by mouth or injection (systemic therapy). It is not known if OGSIVEO is safe and effective in children.1


OGSIVEO is a systemic therapy, meaning it works throughout the entire body1,5—unlike surgery which is a local therapy, meaning it is typically focused on a single place in the body.6

Is OGSIVEO chemotherapy?

OGSIVEO is not a chemotherapy. It is a systemic therapy, meaning it works throughout the entire body1,5—unlike surgery which is a local therapy, meaning it is typically focused on a single place in the body.6


OGSIVEO is thought to work by interfering with gamma secretase—a protein that helps some types of cells grow, including desmoid tumor cells. OGSIVEO may keep desmoid tumor cells from growing.2,7 The precise mechanism of how OGSIVEO works is not known.

Is OGSIVEO injected?

No, OGSIVEO is an oral medicine. The tablets are taken by mouth twice a day, with or without food.1

Learn more about how to take OGSIVEO >

How is OGSIVEO typically taken?

OGSIVEO is convenient to take at home. The recommended dosage of OGSIVEO is 150 mg taken 2 times 
a day.1
OGSIVEO blister packs may help you track your dose more easily with clear AM/PM dosing by day of the week. Each blister pack contains a 7-day supply, and four blister packs provide a 28-day supply.

Learn more about OGSIVEO dosing >

What should I tell my doctor before taking OGSIVEO?

Tell your healthcare provider about all of your medical conditions, including if you have liver problems, are pregnant or plan to become pregnant, and if you are breastfeeding or plan to breastfeed. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. You should avoid taking proton pump inhibitors (PPIs) and H2 blockers during treatment with OGSIVEO. Ask your healthcare provider if you are not sure if you take one of these medicines.1

Learn more about starting OGSIVEO >

How long will I take OGSIVEO?

Talk to your doctors about how long you might take OGSIVEO. In general, your doctor might recommend that you keep taking OGSIVEO unless your tumor grows (progresses), your symptoms worsen, or you have troublesome side effects that cannot be managed, as determined with your doctor. Follow your doctor’s recommendations for how to take OGSIVEO. During the clinical trial, people took OGSIVEO for a time period ranging from less than 1 month to over 
2.5 years.1

Download the OGSIVEO Patient Brochure >

Is OGSIVEO for anyone with a desmoid tumor?

No. OGSIVEO is for adults with progressing desmoid tumors who require systemic therapy. It is not 
known if OGSIVEO is safe and effective in children.1 Talk to your doctor to find out if OGSIVEO might be 
an option for you.

Start a doctor discussion guide to prepare >

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Starting OGSIVEO
What is Ogsiveo?
Important Safety Information

What is OGSIVEO?  

OGSIVEO is a prescription medication used to treat adults with progressing desmoid tumors who require a medicine by mouth or injection (systemic therapy). It is not known if OGSIVEO is safe and effective in children.

Important Safety Information  

Before taking OGSIVEO tell your healthcare provider about all of your medical conditions, including if you:

  • Have liver problems.
  • Are pregnant or plan to become pregnant. OGSIVEO can harm your unborn baby. Tell your healthcare provider if you become pregnant or think you may be pregnant during treatment.
  • Females who are able to become pregnant:
    • Your healthcare provider will give you a pregnancy test before you start treatment with OGSIVEO.
    • You should use effective birth control during treatment and for 1 week after the last dose. Talk to your healthcare provider about methods that may be right for you.
    • Stop taking OGSIVEO and tell your healthcare provider right away if you become pregnant.
  • Males with female partners who are able to become pregnant should use effective birth control during treatment with OGSIVEO and for 1 week after the last dose.
  • Are breastfeeding or plan to breastfeed. It is not known if OGSIVEO passes into your breast milk. Do not breastfeed during treatment with OGSIVEO and for 1 week after the last dose.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

You should avoid taking proton pump inhibitors (PPIs) and H2 blockers during treatment with OGSIVEO. Ask your healthcare provider if you are not sure if you take one of these medicines. 

How should I take OGSIVEO? 

  • Take OGSIVEO exactly as your healthcare provider tells you to take it.
  • Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment with OGSIVEO if you develop side effects.
  • Take OGSIVEO 2 times a day with or without food.
  • Swallow OGSIVEO tablets whole. Do not break, crush, or chew.
  • If you take an antacid medicine, take OGSIVEO 2 hours before or 2 hours after the antacid.
  • If you vomit after taking a dose or miss a dose of OGSIVEO, take your next dose at your regular time. Do not take 2 doses of OGSIVEO to make up the dose.

What should I avoid while taking OGSIVEO? 

Avoid eating or drinking grapefruit products, Seville oranges, and starfruit during treatment with OGSIVEO.  

What are the possible side effects of OGSIVEO? 

OGSIVEO can cause serious side effects, including:

  • Diarrhea. Diarrhea is common with OGSIVEO and may sometimes be severe. Your healthcare provider may tell you to drink more fluids or to take antidiarrheal medicines. Tell your healthcare provider right away if you have diarrhea that lasts longer than a few days and does not get better after taking antidiarrheal medicines.
  • Ovarian problems. Females who are able to become pregnant may have ovarian problems and changes in their menstrual cycle during treatment. OGSIVEO may affect fertility which may affect your ability to have a child. Tell your healthcare provider if you have any changes in your menstrual cycle or hot flashes, night sweats, or vaginal dryness during treatment.
  • Liver problems. OGSIVEO can increase liver enzymes. Your healthcare provider will do blood tests to check your liver function before you start and during treatment with OGSIVEO.
  • New non-melanoma skin cancers. Your healthcare provider will do skin exams before and during treatment with OGSIVEO if you are at risk for skin cancer. Tell your healthcare provider if you have any new or changing skin lesions.
  • Electrolyte (salt) problems. Your healthcare provider will do blood tests to check your phosphate and potassium levels during treatment and may give you medicines to treat low phosphate or low potassium if needed. Tell your healthcare provider if you develop any muscle pain or weakness.

Tell your healthcare provider right away if you have any side effect that bothers you or that does not go away. Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment with OGSIVEO.  

The most common side effects of OGSIVEO are: 

  • rash 
  • nausea 
  • tiredness 
  • mouth sores 
  • headache 
  • stomach (abdominal) pain 
  • cough 
  • hair loss 
  • upper respiratory infection 
  • shortness of breath 

OGSIVEO can affect fertility in females and males, which may affect your ability to have a child. Talk to your healthcare provider if this is a concern for you.
These are not all of the possible side effects of OGSIVEO. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Please see full Prescribing Information and Patient Information for OGSIVEO.

What is OGSIVEO?  

OGSIVEO is a prescription medication used to treat adults with progressing desmoid tumors who require a medicine by mouth or injection (systemic therapy). It is not known if OGSIVEO is safe and effective in children.

Please see full Prescribing Information and Patient Information for OGSIVEO.

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References
  1. OGSIVEO. Prescribing Information. SpringWorks Therapeutics, Inc.
  2. Data on file. SpringWorks Therapeutics, Inc. June 2025.
  3. Referenced with permission from the NCCN Guidelines for Patients® for Soft Tissue Sarcoma, 2025. © National Comprehensive Cancer Network, Inc. 2025. All rights reserved. Accessed August 7, 
2025. To view the most recent and complete version of the NCCN Guidelines for Patients, go online to NCCN.org/patientguidelines. NCCN makes no warranties of any kind whatsoever regarding their content, use, or application, and disclaims any responsibility for their application or use in any way.
  4. Gounder M, Ratan R, Alcindor T, et al. Nirogacestat, a gamma-secretase inhibitor for desmoid tumors. N Engl J Med. 2023;388(10):898-912.